The report “A Trans-European CO2 Transportation Infrastructure for CCUS: Opportunities & Challenges” aims to provide a technical overview on CO2 transportation, in particular the use of pipeline networks in industrial clusters, and it stresses the importance of developing dedicated business models for CO2 transportation. The report highlights the need for further development of the key principles underpinning the development of CO2 transportation pipelines and large-scale deployment and identifies legal barriers to CO2 pipeline transportation. While the role of CCS/CCUS and its contribution towards mitigating climate change are acknowledged, a strong signal from European policymakers in support of European cross-border CO2 infrastructure will be necessary.